Patrick Dempsey can recently be seen in Michael Mann's new film, Ferrari, in which he stars opposite Adam Driver and Penélope Cruz, as well as Eli Roth's Thanksgiving. Patrick can be seen starring in the Disney+ feature film and sequel to Enchanted, Disechanted, opposite Amy Adams and Clyde Phillips's Dexter: Original Sin, opposite Christian Slater. He will be making a highly anticipated return to broadcast TV as the lead in Memory of a Killer, Fox’s straight-to-series thriller about a hitman who develops early onset Alzheimer’s.

On the television, Patrick starred in the Lux Vide/Fremantle SKY-Italy television series, Devils that aired throughout Europe. Other recent credits include Universal’s Bridget Jones's Baby alongside Renee Zellweger and Colin Firth, and the EPIX mini-series The Truth About The Harry Quebert Affair.

Patrick is well-known for his portrayal of Dr. Derek Shepherd on the hit ABC series, Grey's Anatomy. His performance earned him a 2007 Screen Actors Guild Award and was nominated in 2006 and 2007 for a Golden Globe for Best Performance by an Actor in a Television Series – Drama.

Patrick’s other film credits include: Transformer: Dark Side of the Moon, Valentine's Day, Made of Honor, Freedom Writers, Sweet Home Alabama, Scream 3, With Honors, Outbreak, Hugo Pool, The Treat, The Palace Thief, Heaven Help Us, Happy Together, Some Girls, Coupe de Ville, Run, Mobsters, and In the Mood. He became well known from such classic ‘80s nostalgia films such as, Can't Buy Me Love and Loverboy.

Patrick has multiple brand relationships including Porsche and Tag Heuer, was named 2023’s People Magazine’s Sexiest Man Alive and founded The Dempsey Center  on behalf of his mother and for the benefit of families dealing with cancer.